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The deuteration of acetanilides

✍ Scribed by Siow K. Chin; Robin Collier; David W. Hutchinson

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
198 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The base‐catalysed exchange of a proton of the methyl groups in acetanilides can be used to incorporate deuterium into these amides. 4′‐Hydroxy‐2[^2^H]acetanilide (acetaminophen, paracetamol) can be prepared by the demethylation with boron tribromide of 4′‐methoxy‐2[^2^H]acetamide obtained by this base‐catalysed exchange.

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