A liquid chromatographic method for the determination of mexiletine and unconjugated metabolites in plasma has been developed. A reversed-phase C18 column is used with isocratic elution and either UV or amperometric detection. Sample pretreatment involves double extraction of the metabolites. The me
The determination of metabolites of garlic preparations in breath and human plasma
β Scribed by Rober T. T. Rosen; Richard D. Hiserodt; Elaine K. Fukuda; Reginald J. Ruiz; Zhengyi Zhou; Joseph Lech; Sharon L. Rosen; Thomas G. Hartman
- Book ID
- 112010420
- Publisher
- IOS Press
- Year
- 2000
- Tongue
- English
- Weight
- 74 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0951-6433
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π SIMILAR VOLUMES
Pre-column derivatization with o-phthaldialdehyde and N-acetyl-l-cysteine was used for liquid-chromatographic diastereomeric resolution of p-hydroxymexiletine (PHM) and hydroxymethylmexiletine (HMM), metabolites of mexiletine formed by aromatic and aliphatic hydroxylation, respectively. The resultin
Two rapid, sensitive, and specific gas chromatographic (GC) methods for the quantitative determination of quazepam (I), 7-chloro-5-(2fluorophenyl-1,3-dihydro-1 -(2,2,2-trifluoroethyl)-2H -1,4-benzodiazepine-Zthione, and its major active plasma metabolites, the 2-0x0 compound (11) and the dealkylated