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Determination of the metabolites of mexiletine in human plasma

✍ Scribed by K. Selinger; J.C. Crawhall

Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
279 KB
Volume
3
Category
Article
ISSN
0731-7085

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✦ Synopsis

A liquid chromatographic method for the determination of mexiletine and unconjugated metabolites in plasma has been developed. A reversed-phase C18 column is used with isocratic elution and either UV or amperometric detection. Sample pretreatment involves double extraction of the metabolites. The method enables the measurement of four mexiletine metabolites at levels as low as 10 ng m1-1, with both precision and accuracy of about 6%. Forty-nine samples from patients receiving mexiletine were analysed. Metabolite VII was found to be the major metabolite (mean concentration 225 ng Β’n1-1), metabolites IX and VI were also found at mean concentrations of 95 and 10 ng m1-1, respectively, whilst metabolite VIII was not detected.

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