The determination of mean residence time using statistical moments:It is correct
β Scribed by William R. Gillespie; Peter Veng-Pedersen
- Book ID
- 112472354
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 293 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1573-8744
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
This paper simulates the sampling distributions of the rate parameter and the mean residence time (MRT) estimators for a specific two-compartment model. Two forms of measurement error, one additive and the other multiplicative, and two forms of weighting structures, one unweighted and the other wei
Moment analysis has become widely used in recent years as a noncompartmental approach to the estimation of mean residence time (MRT) and steady-state volume of distribution (Vd,,) from single-dose data.1-5 In 1983, the method was first extended to the multiple-dosing situation by Bauer and Gibaldi.6
Purpose: The goal of this study was to develop a new method, based on robust pharmacokinetic (PK) parameters, for determining t max (time of peak plasma concentration) and the magnitude of difference between the absorption (k a ) and elimination (k) rate constants in the one compartment body model w