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The detection of major loci by segregation and linkage analysis: A simulation study

✍ Scribed by Dr. Lynn R. Goldin; Nancy J. Cox; David L. Pauls; Elliot S. Gershon; Kenneth K. Kidd; D. C. Rao

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
797 KB
Volume
1
Category
Article
ISSN
0741-0395

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## Abstract What happens to the results of linkage analysis when one assumes that a disease results from a single genetic locus with reduced penetrance when the actual cause is two epistatically interacting loci? We wanted to (1) determine whether assuming the correct mode of inheritance at the lin