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Two-locus approach of segregation and linkage analysis in the study of complex traits

✍ Scribed by Dr. Jianfeng Xu; Eugene W. Taylor; Carolien I. M. Panhuysen; Valerie L. Prenger; Rebecca Koskela; Bart Kiemeney; Michele C. LaBuda; Nancy E. Maestri; Deborah A. Meyers

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
318 KB
Volume
12
Category
Article
ISSN
0741-0395

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✦ Synopsis

A two-locus segregation and linkage-analysis approach was used to characterize the genetic control of a complex trait (Ql) and to localize the genes that have detectable effects. The results suggested that a two-locus Mendelian model fit the data significantly better than a one-locus model. The linkage results based on the most parsimonious two-locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one-locus models. Results also suggested that the subphenotypes (Q2 and 43) provided useful information for further analysis of Q1 using two-locus models.

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