The t(1;19)(q23;p13), detected cytogenetically in 5-6% of cases, is one of the most common translocations in childhood acute lymphoblastic leukemia (ALL). Most t(1;19)Ο© ALLs are pseudodiploid or contain fewer than 50 chromosomes, are classified as pre-B based on expression of cytoplasmic, but not su
The detection of E2A rearrangement or E2A-PBXI fusion transcript in t(1;19) leukemia to the editors
β Scribed by Prema E. Devaraj; Letizia Foroni; Lorna M. Secker-Walker; Iwona Wlodarska; Michel Stul; Chris De Wolf-Peeters; Gregor Verhoef; Cristina Mecucci; Jean-Jacques Cassiman; Herman van den Berghe
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 208 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1045-2257
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## Abstract Translocation t(1;19)(q23;p13) plays a crucial role in the pathogenesis of childhood preβB cell leukemia and results in the formation of a fusion gene E2AβPBXI that encodes a hybrid transcription factor with oncogenic potential. Here we describe two cases, one follicular lymphoma and on
We present a case of acute myelomonoblastic leukemia with marrow eosinophilia (M4Eo) having inv( 16) developed after etoposide administration for chronic type adult T-cell leukemia (ATL). A 74-year-old Japanese woman was admitted in April 1993 because of a fungal infection on the chest skin that occ