t(1;19) without detectable E2A rearrangements in two t(14; 18)-positive lymphoma/leukemia cases

✍ Scribed by Iwona Wlodarska; Michel Stul; Chris De Wolf-Peeters; Gregor Verhoef; Cristina Mecucci; Jean-Jacques Cassiman; Herman Van Den Berghe

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 521 KB
• Volume: 10
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870100304

✦ Synopsis

Abstract

Translocation t(1;19)(q23;p13) plays a crucial role in the pathogenesis of childhood pre‐B cell leukemia and results in the formation of a fusion gene E2A‐PBXI that encodes a hybrid transcription factor with oncogenic potential. Here we describe two cases, one follicular lymphoma and one acute lymphoblastic leukemia/lymphoma, characterized by a complex karyotype including t(14;18), t(8;14), as well as t(1;19). Molecular studies in both cases failed to show rearrangements of the E2A gene. These results suggest that the t(1;19) found as a secondary chromosome change in t(14;18)‐positive lymphoma/leukemia might be a molecular variant of the t(1;19) that is typical of childhood pre‐B cell leukemia. Genes Chromosom Cancer 10:171–176 (1994). © 1994 Wiley‐Liss, Inc.