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Detection of the PEBP2?/MYH11 fusion transcript in acute myelomonoblastic leukemia (M4Eo) supervening in a patient with adult T-cell leukemia

✍ Scribed by Osato, Motomi; Asou, Norio; Takata, Nobukatsu; Suzushima, Hitoshi; Takatsuki, Kiyoshi; Kawano, Fumio

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
73 KB
Volume
55
Category
Article
ISSN
0361-8609

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✦ Synopsis

We present a case of acute myelomonoblastic leukemia with marrow eosinophilia (M4Eo) having inv( 16) developed after etoposide administration for chronic type adult T-cell leukemia (ATL). A 74-year-old Japanese woman was admitted in April 1993 because of a fungal infection on the chest skin that occurred 5 months before. The leukocyte count was 28.9 Γ— 10 9 /l with 61% abnormal lymphocytes showing lobulated nuclei and expressing CD4 antigen. The serum was positive for anti-HTLV-I antibody. She was diagnosed as chronic type ATL and treated with two courses of 75 mg of etoposide orally for 21 days. The leukocyte counts decreased

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