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The Design, Synthesis, and Evaluation of Coumarin Ring Derivatives of the Novobiocin Scaffold that Exhibit Antiproliferative Activity

โœ Scribed by Donnelly, Alison C.; Mays, Jared R.; Burlison, Joseph A.; Nelson, John T.; Vielhauer, George; Holzbeierlein, Jeffrey; Blagg, Brian S. J.


Book ID
127260100
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
677 KB
Volume
73
Category
Article
ISSN
0022-3263

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The synthesis and evaluation of some cou
โœ Arthur L. James; John D. Perry; Stephen P. Stanforth ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 70 KB

The carbamate 8 was reacted with appropriate ฮฒ-keto esters in a Pechmann reaction giving the coumarin derivatives 9-11 bearing 4-nitrobenzylcarbamoyl triggers. These compounds were assessed as potential indicators of nitroreductase activity.