The synthesis and evaluation of some coumarin derivatives as fluorescent indicators of nitroreductase activity

✍ Scribed by Arthur L. James; John D. Perry; Stephen P. Stanforth

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2006
• Tongue: English
• Weight: 70 KB
• Volume: 43
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570430241

✦ Synopsis

The carbamate 8 was reacted with appropriate β-keto esters in a Pechmann reaction giving the coumarin derivatives 9-11 bearing 4-nitrobenzylcarbamoyl triggers. These compounds were assessed as potential indicators of nitroreductase activity.