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The Design and Synthesis of Sulfonamides as Caspase-1 Inhibitors.

✍ Scribed by William G. Harter; Hans Albrecht; Kenneth Brady; Bradley Caprathe; James Dunbar; John Gilmore; Sheryl Hays; Catherine R. Kostlan; Beth Lunney; Nigel Walker


Publisher
John Wiley and Sons
Year
2004
Weight
67 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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Synthesis of functionally diverse bicycl
✍ Stephen Hanessian; Helen Sailes; Eric Therrien πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 266 KB

Bicyclic sulfonamides were synthesized from 4-alkenyl N-alkenylsulfonyl L-prolines using a ring-closure metathesis reaction. Three types of bicyclic sulfonamides varying in the size of the second ring (5,5; 5,6; 5,7) were synthesized. A sulfonamide counterpart of an indolizidinone 2-carboxylic acid