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The design and synthesis of a 5-HETE affinity chromatography ligand for 5-hydroxyeicosanoid dehydrogenase

✍ Scribed by Subhash P Khanapure; Goutam Saha; William S Powell; Joshua Rokach

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 162 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00971-0

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✦ Synopsis

The ®rst total synthesis of an o-amino 5-HETE derivative 27 has been accomplished by a new counterclockwise strategy, in which C-1 is constructed ®rst and C-20 last. The o-amino 5-HETE derivative was transformed to an anity chromatography ligand, the biotinylated 5-HETE 30. This anity chromatography ligand is aimed at purifying the 5-hydroxyeicosanoid dehydrogenase enzyme, which is responsible for the conversion of 5-HETE to 5-oxo-ETE, a potent eosinophil chemotactic factor.

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