𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The cytoplasmic trafficking of DNA topoisomerase IIα correlates with etoposide resistance in human myeloma cells

✍ Scribed by Roxane Engel; Nikola I Valkov; Jana L Gump; Lori Hazlehurst; William S Dalton; Daniel M Sullivan

Book ID
116980930
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
690 KB
Volume
295
Category
Article
ISSN
0014-4827

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Ectopic expression of human topoisomeras
Ectopic expression of human topoisomerase IIα fragments and etoposide resistance in mammalian cells
✍ Angelika I. Ernst; Alex Soltermann; Jürg A. Sigrist; Lukas Widmer; Susan M. Gass 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 596 KB

Cellular resistance to etoposide has been correlated both with reduced levels and an aberrant cytoplasmic accumulation of the drug's target, topoisomerase II␣ (topo II␣). It is not known, however, whether a cytoplasmic pool of topo II␣ is sufficient to confer drug resistance on cultured mammalian ce