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Increased Phosphorylation of DNA Topoisomerase II in Etoposide Resistant Mutants of Human Glioma Cell Line

✍ Scribed by Y. Matsumoto; K. Kunishio; S. Nagao


Book ID
110234490
Publisher
Springer US
Year
1999
Tongue
English
Weight
90 KB
Volume
45
Category
Article
ISSN
0167-594X

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Cellular resistance to etoposide has been correlated both with reduced levels and an aberrant cytoplasmic accumulation of the drug's target, topoisomerase II␣ (topo II␣). It is not known, however, whether a cytoplasmic pool of topo II␣ is sufficient to confer drug resistance on cultured mammalian ce