Cellular resistance to etoposide has been correlated both with reduced levels and an aberrant cytoplasmic accumulation of the drug's target, topoisomerase II␣ (topo II␣). It is not known, however, whether a cytoplasmic pool of topo II␣ is sufficient to confer drug resistance on cultured mammalian ce
✦ LIBER ✦
Decreased levels of topoisomerase IIα in human renal cell carcinoma lines resistant to etoposide
✍ Scribed by Johan M. W. Scheltema; Johan C. Romijn; Gert J. van Steenbrugge; William T. Beck; Fritz H. Schröder; Gerald H. Mickisch
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 326 KB
- Volume
- 123
- Category
- Article
- ISSN
- 1432-1335
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