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The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal

✍ Scribed by Nobuto Arashiki; Yayoi Otsuka; Daisuke Ito; Mira Yang; Tomohiko Komatsu; Kota Sato; Mutsumi Inaba

Book ID: 116299685
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 550 KB
Volume: 391
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.12.121

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## Abstract The aim of this work was to synthesize ^13^C internal standards for the quantification of 4‐hydroxy‐2(E)‐nonenal (HNE), a lipid peroxidation product, and of the etheno‐adducts possibly formed by HNE damage to DNA nucleobases. We designed an eight‐step synthesis starting from ethyl 2‐bro