## Abstract Cytochrome __c__ is a key mitochondrial respiratory protein that is particularly susceptible to modification during oxidative stress. The nature of this susceptibility is linked to the mitochondrial membrane being rich in esterified linoleic acid, which predisposes this organelle to the
Mass Spectrometric Characterization of Modifications to Angiotensin II by Lipid Peroxidation Products, 4-Oxo-2(E)-nonenal and 4-Hydroxy-2(E)-nonenal
✍ Scribed by Lee, Seon Hwa; Takahashi, Ryo; Goto, Takaaki; Oe, Tomoyuki
- Book ID
- 115511303
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 610 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0893-228X
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## Abstract Several pieces of evidence indicate that albumin modified by HNE is a promising biomarker of systemic oxidative stress and that HNE‐modified albumin may contribute to the immune reactions triggered by lipid peroxidation‐derived antigens. In this study, we found by HPLC analysis that HNE
## Abstract The aim of this work was to synthesize ^13^C internal standards for the quantification of 4‐hydroxy‐2(E)‐nonenal (HNE), a lipid peroxidation product, and of the etheno‐adducts possibly formed by HNE damage to DNA nucleobases. We designed an eight‐step synthesis starting from ethyl 2‐bro