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Identification of Novel Urinary Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in Rats

✍ Scribed by Alary, Jacques; Debrauwer, Laurent; Fernandez, Yvette; Paris, Alain; Cravedi, Jean-Pierre; Dolo, Laurence; Rao, Dinesh; Bories, Georges

Book ID
127250063
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
240 KB
Volume
11
Category
Article
ISSN
0893-228X

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Synthesis of the lipid peroxidation prod
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## Abstract The aim of this work was to synthesize ^13^C internal standards for the quantification of 4‐hydroxy‐2(E)‐nonenal (HNE), a lipid peroxidation product, and of the etheno‐adducts possibly formed by HNE damage to DNA nucleobases. We designed an eight‐step synthesis starting from ethyl 2‐bro