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The correlation of polymer-water and octanol-water partition coefficients: estimation of drug solubilities in polymers

✍ Scribed by Pitt, Colin G.; Bao, Yen T.; Andrady, Anthony L.; Samuel, Peter N.K.

Book ID: 123147013
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 917 KB
Volume: 45
Category: Article
ISSN: 0378-5173
DOI: 10.1016/0378-5173(88)90028-2

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Water (2.3 M ) dissolved in octanol( 6) reduces solute solubility in octanol, while octanol(4.5 X lO-3M) in water (9) enhances solute solubility in water. To support this point, the solubilities of these three compounds in water-saturated octanol are shown to be reduced by -10-30% because of water s