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Correlation of water solubility with octanol-water partition coefficient: A response

✍ Scribed by Samuel H. Yalkowsky; Shri C. Valvani

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 233 KB
Volume: 70
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600701028

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✦ Synopsis

Water (2.3 M ) dissolved in octanol( 6) reduces solute solubility in octanol, while octanol(4.5 X lO-3M) in water (9) enhances solute solubility in water. To support this point, the solubilities of these three compounds in water-saturated octanol are shown to be reduced by -10-30% because of water saturation. These results suggest that octanol in water promotes water solubility by -75% for 111,70% for 11, and 150% for I.

Based on these findings, the use of experimental partition coefficients probably would improve the reliability of the log S-log P correlation at the high P region.

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