The Conformational Equilibrium in N,N′-Dimethylpiperazine

✍ Scribed by F.A.L. Anet; Issa Yavari

• Publisher: Elsevier Science
• Year: 1976
• Tongue: French
• Weight: 225 KB
• Volume: 17
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)93127-7

✦ Synopsis

Recent investigations

of a variety of substituted N-methylpiperidines indicate that the N-methyl group of g-methylpiperidine prefers the equatorial over the axial orientation by about -2.5 to 3.0 kcal/mol,1-5 a value considerably higher then that found in methylcyclohexane. 6,7 we now report on the axial-equatorial energy difference in N,E-dimethylpiperazine CI,, a compound