The first asymmetric synthesis of the naturally occurring (+)-Kotanin is described. The key steps involve the intramolecular oxidative coupling of the cyanocuprate intermediate and the Fries rearrangement. The absolute configuration of (+)-Kotanin was assigned as aS by CD spectroscopic method. (~) 1
The configuration of (−) tropic acid and of its naturally occurring esters
✍ Scribed by G. Fodor; Gy. Csepreghy
- Publisher
- Elsevier Science
- Year
- 1959
- Tongue
- French
- Weight
- 120 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0040-4039
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The First Asymmetric Synthesis of the Naturally Occurring (+)-Kotanin and the Assignment of Its Absolute Configuration. -The key steps in the synthesis of the title compound (IX) are cyclization of the dibromide (II) and Fries rearrangement of the diacetate derived from the diol (IV). The absolute
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