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The Concept of Additivity of Drug Combinations in the Case of Quantal Response

✍ Scribed by Dr. Th. Wolf; Dr. H.-D. Unkelbach

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
449 KB
Volume
27
Category
Article
ISSN
0323-3847

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✦ Synopsis

The concept of additivity of drug combinations is widely accepted in pharmacology and toxicology. Up to now, no general statistical methods to test that property are available. The present paper gives a mathematical formulation of additivity, a method to fit dose response surfaces under additivity assumption and a statistical test.

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