𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacogenomics: The Genomics of Drug Response

✍ Scribed by March, Ruth

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
89 KB
Volume
1
Category
Article
ISSN
0749-503X

No coin nor oath required. For personal study only.

✦ Synopsis

Pharmacogenomics is defined as the study of the association between genetics and drug response. This is a rapidly expanding field with the hope that, within a few years, prospective genotyping will lead to patients being prescribed drugs which are both safer and more effective (β€˜the right drug for the right patient’, or personalized medicine). There are many existing examples in the literature of strong associations between genetic variation and drug response, and some of these even form the basis of accepted clinical tests. The molecular basis for some of these associations is described, and includes examples of variation in genes responsible for absorption and metabolism of the drug, and in target and disease genes. However, there are many issues surrounding the legal, regulatory and ethical framework to these studies that remain unanswered, and a huge amount of education both for the public and haelthcare professionals will be needed bafore the results of this new madicine can be widely accepted.

πŸ“œ SIMILAR VOLUMES

Impact of genomics on therapeutic drug d
Impact of genomics on therapeutic drug development
✍ Giulia C. Kennedy πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 156 KB πŸ‘ 2 views

Genomics is defined as a set of related technologies which are focused on the discovery of genes implicated in human disease. Although many of the estimated 100,000 genes in the human genome have been at least partially identified by nucleotide sequence, elucidation of biological function has been a

Application of genetics and genomics in
Application of genetics and genomics in drug development
✍ Mihael H. Polymeropoulos πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 54 KB πŸ‘ 2 views

Pharmacogenetics is capitalizing on the tools of the Human Genome Project to introduce the new genomic information into drug development. The applications vary from identifying individuals at risk for a disease, to developing gene signatures of drug efficacy and adverse effects. Pharmacogenetics is

Integrating expression-based drug respon
Integrating expression-based drug response and SNP-based pharmacogenetic strategies into a single comprehensive pharmacogenomics program
✍ Bonnie E. Gould Rothberg; Tennore M. Ramesh; Catherine E. Burgess πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 410 KB πŸ‘ 1 views

In the third millennium, competitive advantage in drug development will derive from expertise in two areas: 1) the ability to prioritize and triage hits from a combinatorial chemistry/high-throughput screening experiment and pursue only those hits most likely to succeed through clinical development,

Strategies for the application of functi
Strategies for the application of functional genomics technology to biopharmaceutical drug discovery
✍ Pennina R. Langer-Safer; Lori J. Fitz; Maryann Z. Whitley; Clive R. Wood; David πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 369 KB πŸ‘ 1 views

We have developed a strategy to apply genomics and functional genomics-based technologies to the discovery of novel proteins which represent potential therapeutic candidates. The core of this strategy is based on a process for the high-throughput discovery, full-length cDNA cloning and expression of