Genetics and genomics are altering the drug discovery process and changing the practice of medicine. Genetic mapping and positional cloning will lead to the identification of disease susceptibility alleles of different genes and this will be further enabled by the publication of the DNA sequence of
Application of genetics and genomics in drug development
β Scribed by Mihael H. Polymeropoulos
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 54 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
β¦ Synopsis
Pharmacogenetics is capitalizing on the tools of the Human Genome Project to introduce the new genomic information into drug development. The applications vary from identifying individuals at risk for a disease, to developing gene signatures of drug efficacy and adverse effects. Pharmacogenetics is a field in evolution from which significant growth is expected in the years to come. Drug Dev. Res.
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Genomics is defined as a set of related technologies which are focused on the discovery of genes implicated in human disease. Although many of the estimated 100,000 genes in the human genome have been at least partially identified by nucleotide sequence, elucidation of biological function has been a
Pharmacogenomics is defined as the study of the association between genetics and drug response. This is a rapidly expanding field with the hope that, within a few years, prospective genotyping will lead to patients being prescribed drugs which are both safer and more effective (βthe right drug for t