The common regulatory pathway of MHC class I and class II transactivation
β Scribed by Peter J van den Elsen; Sam J.P Gobin
- Book ID
- 108489087
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 150 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1286-4579
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ranscription of major histocompatibility complex (MHC) class II genes is controlled by a number of transcription factors that interact with a set of conserved cisacting regulatory elements within the promoter region of MHC class II genes. These regulatory sequences include the W/S, X1, X2 and Y-box
In order to develop an effective immunotherapy for hematological malignancies, we investigated the applicability of class II transactivator (CIITA), which had been demonstrated to regulate the expression of MHC class II (MHC-II) by assembling the transcription factors of MHC-II molecules, for immuno