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Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

✍ Scribed by Cheong-Hee Chang; Sylvie Guerder; Soon-Cheol Hong; Willem van Ewijk; Richard A Flavell

Book ID
117723010
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
371 KB
Volume
4
Category
Article
ISSN
1074-7613

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Activation of T lymphocytes is quantitatively controlled by the level of expression of MHC class II molecules. Both constitutive and inducible expression of MHC class II genes is regulated by the transactivator CIITA, which is itself tightly regulated. Since the level of MHC class II molecules expre