Regulation of Class II MHC Expression in APCs: Roles of Types I, III, and IV Class II Transactivator
β Scribed by Pai, R. K.; Askew, D.; Boom, W. H.; Harding, C. V.
- Book ID
- 127238588
- Publisher
- American Association of Immunologists
- Year
- 2002
- Tongue
- English
- Weight
- 480 KB
- Volume
- 169
- Category
- Article
- ISSN
- 0022-1767
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## Abstract We first classified 12 malignant glioma cell lines into three different groups (types 1β3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type
In order to develop an effective immunotherapy for hematological malignancies, we investigated the applicability of class II transactivator (CIITA), which had been demonstrated to regulate the expression of MHC class II (MHC-II) by assembling the transcription factors of MHC-II molecules, for immuno