In order to develop an effective immunotherapy for hematological malignancies, we investigated the applicability of class II transactivator (CIITA), which had been demonstrated to regulate the expression of MHC class II (MHC-II) by assembling the transcription factors of MHC-II molecules, for immuno
The Role of the Class II Transactivator (CIITA) in MHC Class I and II Regulation and Graft Rejection in Kidney
β Scribed by Tasha N. Sims; Marjan Afrouzian; Joan Urmson; Lin-Fu Zhu; Philip F. Halloran
- Book ID
- 114423334
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 417 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1600-6135
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## Abstract We first classified 12 malignant glioma cell lines into three different groups (types 1β3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type
Activation of T lymphocytes is quantitatively controlled by the level of expression of MHC class II molecules. Both constitutive and inducible expression of MHC class II genes is regulated by the transactivator CIITA, which is itself tightly regulated. Since the level of MHC class II molecules expre