The Cholinergic Synapse

✍ Scribed by V. P. Whittaker (auth.), Professor Dr. Victor P. Whittaker (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1988
• Tongue: English
• Leaves: 765
• Series: Handbook of Experimental Pharmacology 86
• Edition: 1
• Category: Library

✦ Synopsis

One of the most impressive works of scholarship in the field of experimental pharmacology has been the Heffter-Heubner Handbuch der experimentellen Pharmakologie, internationalized some years ago under the title Handbook 0/ Experimental Pharmacology and kept up to date by a series of numbered Ergiin­ zungswerke or supplementary volumes which have now replaced in importance the original Handbuch. These volumes constitute a valuable and continuously up­ dated multi author review series of topics important in modern pharmacology and allied sciences. The Editorial Board of the Handbook invited me 2 years ago to undertake, as subeditor, the preparation of a new volume entitled The Cholinergic Synapse. A previous volume in this series, vol. 15, Cholinesterases and Anticholinesterase Agents, edited by GEORGE KOELLE, was published in 1963 and was far wider in scope than its title suggested: it was, in fact an authoritative summing up of the whole subject of cholinergic function and still has some value today as an account of the state of the art as it was at that time. Since then another excellent review, of a specific cholinergic synapse, has appeared in this series: this was vol. 42, Neuromuscular Junction, edited by ELEANOR ZAIMIS and published in 1976. A third volume, vol. 53, Pharmacology o/Ganglionic Transmission, which appeared in 1980 and was edited by D. A. KHARKEVICH, includes important aspects of autonomic cholinergic function.

✦ Table of Contents

Front Matter....Pages I-XXV
Front Matter....Pages 1-1
Model Cholinergic Systems: An Overview....Pages 3-22
Model Cholinergic Systems: The Electromotor System of Torpedo ....Pages 23-39
Model Cholinergic Systems: The Avian Ciliary Ganglion....Pages 41-54
Front Matter....Pages 55-55
Phylogeny of the Cholinergic Synapse....Pages 57-80
Development of the Cholinergic Synapse: Role of Trophic Factors....Pages 81-100
Front Matter....Pages 101-101
Estimation of Acetylcholine and Choline and Analysis of Acetylcholine Turnover Rates In Vivo ....Pages 103-124
Choline Acetyltransferase and the Synthesis of Acetylcholine....Pages 125-165
Vertebrate Cholinesterases: Structure and Types of Interaction....Pages 167-224
Cholinesterases: Tissue and Cellular Distribution of Molecular Forms and Their Physiological Regulation....Pages 225-265
Structure and Function of the Nicotinic Acetylcholine Receptor....Pages 267-313
Muscarinic Acetylcholine Receptors....Pages 315-345
Front Matter....Pages 347-347
Cholinergic Synaptic Vesicles....Pages 349-382
Isolation of Cholinergic Nerve Terminals....Pages 383-397
Axonal Transport in Cholinergic Neurons....Pages 399-407
The High-Affinity Choline Uptake System....Pages 409-445
Cholinergic-Specific Antigens....Pages 447-463
Cholinergic False Transmitters....Pages 465-477
Cholinergic Co-transmitters....Pages 479-533
Front Matter....Pages 535-535
The Neuromuscular Junction....Pages 537-566
The Electromotor Synapse....Pages 567-579
Front Matter....Pages 535-535
The Autonomic Cholinergic Neuroeffector Junction....Pages 581-595
Front Matter....Pages 597-597
Central Cholinergic Pathways: The Biochemical Evidence....Pages 599-614
Central Cholinergic Pathways: The Histochemical Evidence....Pages 615-631
Central Cholinergic Transmission: The Physiological Evidence....Pages 633-662
Front Matter....Pages 663-663
The Cholinergic System in Aging....Pages 665-695
Disorders of Cholinergic Synapses in the Peripheral Nervous System....Pages 697-724
Central Cholinergic Neuropathologies....Pages 725-743
Back Matter....Pages 745-764

✦ Subjects

Pharmacology/Toxicology; Neurosciences; Neurology; Pharmacy