Synaptic Tagging and Capture: From Synapses to Behavior

✍ Scribed by Sreedharan Sajikumar (eds.)

• Publisher: Springer-Verlag New York
• Year: 2015
• Tongue: English
• Leaves: 278
• Edition: 1
• Category: Library

✦ Synopsis

Serves as a comprehensive introduction and overview of synaptic tagging and capture (STC) and covers the topic from molecular and cellular aspects to behavior. Circa 15 years ago the STC model was proposed to provide a conceptual basis for how short-term memories are transformed into long-term memories. Though the hypothesis remains unconfirmed due to technological limitations, the model is well consolidated and generally accepted in the field. Various researchers have investigated the cellular mechanisms for the formation of long-term memory using the STC model, but this is the first book-length treatments of STC. This volume features an introduction by Prof. Richard Morris and Prof. Cliff Abraham.

✦ Table of Contents

Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
Differential Role of CaMK in Synaptic Tagging and Capture....Pages 3-12
Compartmentalization of Synaptic Tagging and Capture....Pages 13-27
Synaptic Cooperation and Competition: Two Sides of the Same Coin?....Pages 29-44
Neuropsin-Dependent and -Independent Synaptic Tagging and Modulation of Long-Term Potentiation: A Quest for the Associated Signaling Pathway(s)....Pages 45-59
PKA Anchoring and Synaptic Tagging and Capture....Pages 61-78
Activity-Dependent Protein Transport as a Synaptic Tag....Pages 79-98
mTOR and the Regulation of Translational Capacity in Late Forms of Synaptic Plasticity....Pages 99-132
Dopaminergic Neuromodulation in Synaptic Tagging and Capture....Pages 133-142
From Where? Synaptic Tagging Allows the Nucleus Not to Care....Pages 143-153
Front Matter....Pages 155-155
BDNF and TrkB-Mediated Signalling Supports Processes of Metaplasticity and Long-Term Memory Formation....Pages 157-171
Prescient Synapses: Gating Future Neuronal Consciousness Through Synaptic Tagging and Metaplasticity....Pages 173-196
Metaplasticity of Synaptic Tagging and Capture: Memory Beyond the Circle....Pages 197-213
Emotional Tagging and Long-Term Memory Formation....Pages 215-229
The Behavioral Tagging Hypothesis and Its Implications for Long-Term Memory Formation....Pages 231-259
Back Matter....Pages 261-263

✦ Subjects

Neurosciences; Neurochemistry