✦ LIBER ✦

The chemotherapeutic drug melphalan induces breakage of chromosomes regions rearranged in secondary leukemia

✍ Scribed by Zissis Mamuris; Marguerite Prieur; Bernard Dutrillaux; Alain Aurias

Book ID: 119104105
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 688 KB
Volume: 37
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(89)90076-9

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Detection of chromosomal breakage in the

Detection of chromosomal breakage in the 1Q12, 9Q12, and 16Q11.2 regions induced by melphalan in cultured human lymphocytes using multicolor fluorescence in situ hybridization

✍ Eduardo de la Peña; Maik Schuler; David A. Eastmond 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 123 KB

Drug-induced changes in the expression o

Drug-induced changes in the expression of MDR-associated genes: Investigations on cultured cell lines and chemotherapeutically treated leukemias

✍ V. Gekeler; J. Beck; A. Noller; A. Wilisch; G. Frese; M. Neumann; R. Handgreting 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 792 KB

DNA Methylation Changes in the IL-I (2F)

DNA Methylation Changes in the IL-I (2F) Chromosomal Region of Some Radiation-Induced Acute Myeloid Leukaemias Carrying Chromosome 2 Rearrangements

✍ Andrew Silver; Andrew George; Walter Masson; George Breckon; Julie Adam; Roger C 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 841 KB

Acute myeloid leukaemias (AML) arising in irradiated CBA/H mice frequently have breakpoints in the F region of chromosome 2. The closely linked cytokine genes interleukin (/L)-/a and p map to this region, and the p gene is deregulated in some AMLs. Using pulsed-field gel electrophoresis techniques,

NotI linking/jumping clones of human chr

NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors

✍ V.I Kashuba; R.Z Gizatullin; A.I Protopopov; R Allikmets; S Korolev; J Li; F Bol 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 808 KB

Location of breakpoints within the major

Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement-positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes

✍ Dr. Ian Dubé; Julie Dixon; Teresa Beckett; Abraham Grossman; Martha Weinstein; P 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 460 KB

We report the sublocalization of the breakpoint in chromosome 22 in 33 patients with chronic myeloid leukemia (CML) who also had unusual marrow cytogenetics. In 23 patients, the leukemic clones were characterized by Philadelphia (Ph') chromosomes that arose through complex translocations that involv

Frequent clonal loss of heterozygosity (

Frequent clonal loss of heterozygosity (LOH) in the chromosomal region 1p32 occurs in childhood T cell acute lymphoblastic leukemia (T-ALL) carrying rearrangements of the TAL1 gene

✍ Iolascon, A; Faienza, M F; Coppola, B; Moretti, A; Basso, G; Amaru, R; Viganò, G 📂 Article 📅 1997 🏛 Nature Publishing Group 🌐 English ⚖ 85 KB