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Frequent clonal loss of heterozygosity (LOH) in the chromosomal region 1p32 occurs in childhood T cell acute lymphoblastic leukemia (T-ALL) carrying rearrangements of the TAL1 gene

✍ Scribed by Iolascon, A; Faienza, M F; Coppola, B; Moretti, A; Basso, G; Amaru, R; Viganò, G; Biondi, A


Book ID
110053452
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
85 KB
Volume
11
Category
Article
ISSN
0887-6924

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Deregulated expression of the TAL1 gene
✍ Sylvie François; Eric Delabesse; Laurence Baranger; Marie Dautel; Charles Foussa 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 239 KB 👁 1 views

TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL