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The CHEK2 1100delC Mutation Identifies Families with a Hereditary Breast and Colorectal Cancer Phenotype

✍ Scribed by Hanne Meijers-Heijboer; Marijke Wasielewski; Anja Wagner; Antoinette Hollestelle; Fons Elstrodt; Renate van den Bos; Anja de Snoo; Grace Tjon A Fat; Cecile Brekelmans; Shantie Jagmohan; Patrick Franken; Paul Verkuijlen; Ans van den Ouweland; Pamela Chapman; Carli Tops; Gabriela Möslein; John Burn; Henry Lynch; Jan Klijn; Riccardo Fodde; Juul Wijnen; Hans Vasen; Mieke Schutte


Book ID
117854211
Publisher
American Society of Human Genetics
Year
2003
Tongue
English
Weight
957 KB
Volume
72
Category
Article
ISSN
0002-9297

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Colorectal cancer and the CHEK2 1100delC
✍ Mirjam M. de Jong; Ilja M. Nolte; Gerard J. te Meerman; Winette T. A. van der Gr 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 82 KB

## Abstract The __CHEK2__ 1100delC mutation was recently identified as a low‐penetrance breast cancer susceptibility allele. The mutation occurred more frequently in families with clustering of breast and colorectal cancers (CRCs) than in families with clustering of breast cancer only. Hence, the 1