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Frequency of the CHEK2 1100delC mutation among women with early-onset and bilateral breast cancer

✍ Scribed by Dapeng Ding, Ying Zhang, Xiaofeng He, Wei Meng, Wenli Ma, Wenling Zheng


Book ID
118726885
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
80 KB
Volume
14
Category
Article
ISSN
1465-5411

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Correlation of CHEK2 protein expression
✍ Outi Kilpivaara; Jirina Bartkova; Hannaleena Eerola; Kirsi SyrjΓ€koski; Pia Vahte πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 145 KB

The CHEK2 kinase is a tumor suppressor whose activation in response to DNA double-strand breaks contributes to cell cycle arrest or apoptosis. The c.1100delC mutation is associated with familial breast cancer, and tumors from mutation carriers show reduced or absent CHEK2 protein expression. We have