The cellular prion protein is preferentially expressed by CD4+ CD25+ Foxp3+ regulatory T cells
✍ Scribed by Jeremy D. Isaacs; Oliver A. Garden; Gurman Kaur; John Collinge; Graham S. Jackson; Daniel M. Altmann
- Book ID
- 108782342
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 202 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0019-2805
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The transcription factor FOXP3 plays a key role in CD4 + CD25 + regulatory T cell function and represents a specific marker for these cells. Despite its strong association with regulatory T cell function, in humans little is known about the frequency of CD4 + CD25 + cells that express FOXP3 protein
## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a
## Abstract Regulatory T cells (Treg cells) have been well documented to have a crucial physiological role in preventing the development of autoimmune diseases and keeping self‐tolerance. Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the