Expression of FoxP3, a key molecule in CD4+CD25+ regulatory T cells, in adult T-cell leukaemia/lymphoma cells
✍ Scribed by Kennosuke Karube; Koichi Ohshima; Takeshi Tsuchiya; Takahiro Yamaguchi; Riko Kawano; Junji Suzumiya; Atae Utsunomiya; Mine Harada; Masahiro Kikuchi
- Book ID
- 108672686
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 158 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0007-1048
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The transcription factor FOXP3 plays a key role in CD4 + CD25 + regulatory T cell function and represents a specific marker for these cells. Despite its strong association with regulatory T cell function, in humans little is known about the frequency of CD4 + CD25 + cells that express FOXP3 protein
## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a