Role of CD8+ CD25+ Foxp3+ regulatory T cells in multiple sclerosis
✍ Scribed by Jorge Correale; Andrés Villa
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 823 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
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## Abstract Regulatory T cells (Treg cells) have been well documented to have a crucial physiological role in preventing the development of autoimmune diseases and keeping self‐tolerance. Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the
## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a