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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

✍ Scribed by Sørensen, Claus Storgaard; Hansen, Lasse Tengbjerg; Dziegielewski, Jaroslaw; Syljuåsen, Randi G.; Lundin, Cecilia; Bartek, Jiri; Helleday, Thomas

Book ID: 109912398
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 841 KB
Volume: 7
Category: Article
ISSN: 1465-7392
DOI: 10.1038/ncb1212

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## Abstract **Background:** Cell lines that stably over‐express protein kinase C (PKC) δ frequently show a decrease in growth rate and saturation density, leading to the hypothesis that PKCδ has a negative effect on cell proliferation. However, the mode of PKCδ activation, the cell cycle stage requ