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Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling

✍ Scribed by Shuichi Kani; Emiko Nakayama; Akinori Yoda; Nobuyuki Onishi; Nagako Sougawa; Yuki Hazaka; Tsuyoshi Umeda; Kohsuke Takeda; Hidenori Ichijo; Yasuhiro Hamada; Yasuhiro Minami

Book ID: 110091021
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 246 KB
Volume: 12
Category: Article
ISSN: 1356-9597
DOI: 10.1111/j.1365-2443.2007.01100.x

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## Abstract In this study, we first demonstrated that loratadine (LOR), a promising world widely used oral anti‐histamine, effectively inhibits growth of tumors derived from human colon cancer cells (COLO 205) in an in vivo setting. In vitro study demonstrated that the anti‐tumor effects of LOR in