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The brain renin–angiotensin system: a target for novel antidepressants and anxiolytics

✍ Scribed by Paul R. Gard


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
121 KB
Volume
65
Category
Article
ISSN
0272-4391

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Brain extracellular fluid (ECF) concentration of YM992, a novel antidepressant, was determined using brain microdialysis to investigate the high partition of this drug to the brain after systemic administration to rats. Plasma, cerebrospinal fluid (CSF), ECF and brain concentrations were determined