β-secretase as a target for the treatmen
✍
Martin Citron
📂
Article
📅
2002
🏛
John Wiley and Sons
🌐
English
⚖ 490 KB
## Abstract Finding inhibitors of the first step of the amyloid cascade, Aβ~42~ generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, β‐and γ‐secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes we