The biosynthesis of the antibiotic obafluorin from p-aminophenylalanine in Pseudomonas fluorescens

✍ Scribed by Richard B. Herbert; Andrew R. Knaggs

• Book ID: 104217787
• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 209 KB
• Volume: 29
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)82345-x

✦ Synopsis

The separate units which are used to construct the unique p-lactone antibiotic obafluorin (1) in Pseudomonas jluorescens are defined by the results of [v-13C]glucose incorporation. A key intermediate in the biosynthesis of ( 1) is established to be L-p-aminophenylalanine (7); L-p-nitrophenylalanine ( 8) is a relatively insignificant precursor. Similar results were obtained for p-nitrophenylacetic acid (9) which is also a metabolite of Ps. jbrescens.