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The Binding of Low-Affinity and High-Affinity Heparin to Antithrombin : Competition for the Same Binding Site on the Protein

✍ Scribed by Åke DANIELSSON; Ingemar BJÖRK


Book ID
115116864
Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
521 KB
Volume
90
Category
Article
ISSN
1432-1327

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Competitive binding assays for high-affi
✍ Richard W. Schreiber Jr.; Michael A. Letavic; Timothy J. McGahan; Harold B. Whit 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 731 KB

Endogenous ligands complicate radioligand-binding assays of high-affinity binding proteins by obscuring binding sites or by diluting the labeled ligand. We have developed a mathematical model for such systems where radioligand and endogenous ligand are structurally identical. Data which relate radio