The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)
β Scribed by Richard K. Haynes; Simone C. Vonwiller
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 257 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Abstract In the presence of an excess of cysteine, a catalytic amount of a nonβiron transitionβmetal ion (Co^2+^, Cu^2+^, Ni^2+^, Ti^4+^, and Mn^2+^) may also induce cleavage of qinghaosu (artemisinin; **1**) to give those end products previously reported for Fe^2+^βmediated degradation.
Hydroxyl radical production from a range of clinically relevant iron chelators in the presence of hydrogen peroxide was measured using the deoxyribose oxidation assay. Hydroxyl radical production from an iron complex is dependent on whether the ligand is able to completely surround the iron, thereby