Cleavage of Qinghaosu (Artemisinin) Induced by Non-Iron Transition-Metal Ions in the Presence of Excess Cysteine

✍ Scribed by Yikang Wu; He-Hua Liu

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 187 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390249

✦ Synopsis

Abstract

In the presence of an excess of cysteine, a catalytic amount of a non‐iron transition‐metal ion (Co^2+^, Cu^2+^, Ni^2+^, Ti^4+^, and Mn^2+^) may also induce cleavage of qinghaosu (artemisinin; 1) to give those end products previously reported for Fe^2+^‐mediated degradation.