The backbone and side chain conformations of the cyclic tetrapeptide HC-toxin
β Scribed by Paolo Mascagni; Mark Pope; William A. Gibbons; Lynda M. Ciuffetti; Herman W. Knoche
- Book ID
- 115756457
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 361 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
A hydroxide-mediated Fmoc/methyl ester double deprotection procedure followed by an improved bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) cyclisation reaction are reported. This novel methodology was applied to the synthesis of three new HC-toxin analogues.
## Abstract Conformational energies of the 5β²βadenosine monophosphate have been computed as a function of Ο and Ο, of the torsion angles about the sideβchain glycosyl C(1β²)βN(9) and of the mainβchain exocyclic C(4β²)βC(5β²) bonds by considering nonbonded, torsion, and electrostatic interactions. The