A novel double deprotection-peptide cyclisation procedure and its application to the synthesis of analogues of the cyclic tetrapeptide HC-toxin.

✍ Scribed by Richard E Shute; Daniel H Rich

• Book ID: 104227733
• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 318 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)96315-9

✦ Synopsis

A hydroxide-mediated Fmoc/methyl ester double deprotection procedure followed by an improved bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl) cyclisation reaction are reported. This novel methodology was applied to the synthesis of three new HC-toxin analogues.