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The asymmetric synthesis of β-lactam antibiotics - IV. A formal synthesis of thienamycin.

✍ Scribed by David A. Evans; Eric B. Sjogren

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
287 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

Oxidative cleavage of crotonate imide aldol adduct 6b provides the configurationally stable aldehyde 4. Transformation of this aldehyde to enantiomerically pure p-lactams is described.

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